New neplanocin analogues. IV. 2-Fluoroneplanocin A: an adenosine deaminase-resistant equivalent of neplanocin A

Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1688-90. doi: 10.1248/cpb.42.1688.

Abstract

2-Fluoro- and 2-chloroneplanocin A's (2 and 3) were synthesized as an adenosine deaminase resistant-equivalent of neplanocin A, and evaluated for their antitumor and antiviral activities. Of these, 2 was completely resistant to adenosine deaminase and showed more significant antitumor and antiviral activities than neplanocin A.

Publication types

  • Comparative Study

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemistry
  • Adenosine / metabolism
  • Adenosine / pharmacology
  • Adenosine / therapeutic use
  • Adenosine Deaminase / metabolism*
  • Animals
  • Antibiotics, Antineoplastic / chemical synthesis*
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology
  • Antibiotics, Antineoplastic / therapeutic use
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Drug Resistance
  • Fibrosarcoma / drug therapy*
  • Mice
  • RNA Viruses / drug effects*
  • Ribavirin / pharmacology

Substances

  • Antibiotics, Antineoplastic
  • Antiviral Agents
  • Ribavirin
  • neplanocin A
  • Adenosine Deaminase
  • Adenosine