Reversible functional asplenia. Autoimmune hemolytic anemia with thrombocytopenia in chronic lymphocytic leukemia

T Hirano; K Tomiyoshi; H Take; N Watanabe; N Oriuchi; T Inoue; M Naruse; K Endo

Reversible functional asplenia. Autoimmune hemolytic anemia with thrombocytopenia in chronic lymphocytic leukemia

Clin Nucl Med. 1994 Aug;19(8):693-5.

Authors

T Hirano¹, K Tomiyoshi, H Take, N Watanabe, N Oriuchi, T Inoue, M Naruse, K Endo

Affiliation

¹ Department of Nuclear Medicine, Gunma University, School of Medicine, Japan.

PMID: 7955748

Abstract

An enlarged spleen failed to accumulate Tc-99m-labeled phytate, but it showed normal perfusion and uptake of labeled and heat-denatured red blood cells. A blood cell count demonstrated moderately low hemoglobin and hematocrit levels and a markedly low platelet count, and results of direct Coombs' and antiplatelet-antibody (IgG) tests were positive. Steroid therapy resulted in normal splenic function. This case demonstrates reversible functional asplenia caused by reticuloendothelial dysfunction secondary to pure splenic chronic lymphocytic leukemia.

Publication types

Case Reports

MeSH terms

Anemia, Hemolytic, Autoimmune / drug therapy
Anemia, Hemolytic, Autoimmune / etiology*
Erythrocytes
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
Leukemic Infiltration / diagnostic imaging*
Middle Aged
Organotechnetium Compounds*
Phytic Acid*
Prednisolone / therapeutic use
Radionuclide Imaging
Sodium Pertechnetate Tc 99m*
Spleen / diagnostic imaging*
Spleen / pathology
Splenomegaly / diagnostic imaging*
Splenomegaly / etiology
Thrombocytopenia / drug therapy
Thrombocytopenia / etiology*

Substances

Organotechnetium Compounds
technetium phytate
Phytic Acid
Prednisolone
Sodium Pertechnetate Tc 99m