Abstract
The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+ channel expressed in human heart, has been determined by three independent methodologies: somatic cell hybrid mapping, chromosomal microdissection-polymerase chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the short arm of chromosome 3 (band 3p21) by all three approaches. These data are further evidence that striated muscle Na+ channel genes are dispersed in the genome.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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Chromosome Banding
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Chromosome Mapping
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Chromosomes, Human, Pair 3*
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DNA Primers
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Drug Resistance
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Hominidae / genetics*
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Humans
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Hybrid Cells
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In Situ Hybridization, Fluorescence
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Molecular Sequence Data
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Myocardium / metabolism*
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Polymerase Chain Reaction / methods
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Rodentia
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Sodium Channels / drug effects
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Sodium Channels / genetics*
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Tetrodotoxin / pharmacology*
Substances
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DNA Primers
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Sodium Channels
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Tetrodotoxin