Abstract
The study describes a sequential analysis of depression-related physical symptoms and their relationship to imipramine and amitriptyline plasma levels over 4 weeks of treatment in 79 unipolar and bipolar patients hospitalized for major depressive disorder. Insomnia diminished in all patients after 2 weeks of drug administration. After 4 weeks, the sleep of patients whose depressive disorder has significantly improved was nearly normal, whereas patients who remained depressed showed continued sleep impairment. Reductions in loss of appetite, weight and sexual interest paralleled mood improvement. Tricyclic plasma levels significantly correlated with improved sleep. The findings suggest a close link between depressed mood and physical symptoms during recovery from major depressive disorder.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Affect / drug effects
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Amitriptyline / adverse effects
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Amitriptyline / pharmacokinetics
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Amitriptyline / therapeutic use*
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Appetite / drug effects
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Arousal / drug effects
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Bipolar Disorder / blood
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Bipolar Disorder / drug therapy*
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Bipolar Disorder / psychology
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Body Weight / drug effects
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Depressive Disorder / blood
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Depressive Disorder / drug therapy*
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Depressive Disorder / psychology
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Female
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Humans
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Imipramine / adverse effects
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Imipramine / pharmacokinetics
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Imipramine / therapeutic use*
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Libido / drug effects
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Male
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Middle Aged
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Personality Inventory
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Sleep Stages / drug effects
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Somatoform Disorders / blood
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Somatoform Disorders / drug therapy*
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Somatoform Disorders / psychology