Abstract
When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness termed anergy. In this study, signaling through the common gamma chain of the interleukin-2 (IL-2), IL-4, and IL-7 receptors in the presence of antigen was found to be sufficient to prevent the induction of anergy. After culture with IL-2, IL-4, or IL-7, Jak3 kinase was tyrosine-phosphorylated, which correlated with the prevention of anergy. Therefore, a signal through the common gamma chain may regulate the decision of T cells to either clonally expand or enter a state of anergy.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cell Line
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Clonal Anergy / immunology*
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Clone Cells
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HLA-DR7 Antigen / immunology
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Humans
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Interleukins / immunology
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Janus Kinase 3
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Lymphocyte Activation
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Phosphorylation
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Protein-Tyrosine Kinases / metabolism
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Receptors, Antigen, T-Cell / metabolism
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Receptors, Interleukin-2 / immunology
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Receptors, Interleukin-2 / metabolism*
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Signal Transduction*
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
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Tumor Necrosis Factor-alpha / immunology
Substances
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HLA-DR7 Antigen
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Interleukins
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Receptors, Antigen, T-Cell
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Receptors, Interleukin-2
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Tumor Necrosis Factor-alpha
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Protein-Tyrosine Kinases
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JAK3 protein, human
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Janus Kinase 3