The occurrence of bullous pemphigoid (BP) in patients with multiple sclerosis (MS) is uncommon. The aetiology is not clear and several abnormalities of the immune system are reported in both pathologies. We report one additional case in a 40-year-old woman with a 15-year history of MS. BP was confirmed histologically and immunologically. The therapy with steroids was successful and no recurrence of BP was observed after a six month follow-up.