Abstract
Combination effect of UFT and leucovorin against the rat prostatic carcinoma (R-3327) was evaluated by the subrenal capsular assay (SRCA) using nude mice. Anticancer effect of UFT was augmented by co-administration of both low and high dose leucovorin. These results suggest a clinical usefulness of UFT administration with leucovorin for the patients with hormonally refractory advanced prostatic carcinoma.
MeSH terms
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Animals
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Antineoplastic Combined Chemotherapy Protocols / pharmacology*
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Humans
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Leucovorin / administration & dosage
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Leucovorin / pharmacology
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Prostatic Neoplasms / pathology*
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Subrenal Capsule Assay*
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Tegafur / administration & dosage
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Tegafur / pharmacology
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Tumor Cells, Cultured / drug effects
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Uracil / administration & dosage
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Uracil / pharmacology
Substances
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Tegafur
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Uracil
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Leucovorin