Primary extramedullary plasmacytoma in the middle ear: differential diagnosis and management

J Laryngol Otol. 1994 Oct;108(10):868-70. doi: 10.1017/s002221510012835x.

Abstract

Primary extramedullary plasmacytoma (PEP) is an uncommon neoplasm of plasma cell origin which afflicts the head and neck mainly. In this study we report a rare case of a 34-year-old man who presented with left ear tinnitus, hearing loss, blocked feeling and headache. Exploratory tympanotomy revealed a mass extending into the attic and the mastoid antrum. Following canal wall-up mastoidectomy, the tumour was carefully removed. Histological examination (including immunoperoxidase staining) and thorough clinical, laboratory and radiological evaluation revealed an exclusively cytoplasmic monoclonal IgG immunoglobulin PEP. The combination of surgery (including a second-look procedure) and radiotherapy used in this case may be an over-treatment. However, the patient is still disease-free seven years after his first admission to hospital.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Ear Neoplasms / pathology*
  • Ear Neoplasms / radiotherapy
  • Ear Neoplasms / surgery
  • Ear, Middle / pathology*
  • Humans
  • Male
  • Plasmacytoma / pathology*
  • Plasmacytoma / radiotherapy
  • Plasmacytoma / surgery