Abstract
We identify in normal cells the existence of two distinct sites of the transitional endoplasmic reticulum (ER), one housing the Sec23p protein complex (the classical transitional element), the other the coatomer protein complex (the coatomer-rich ER). Experimental conditions that reduce transport from the ER to the Golgi complex lead to the overexpression of this newly defined coatomer-rich ER.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimycin A / analogs & derivatives
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Antimycin A / pharmacology
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Clathrin / analysis
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Clathrin / metabolism
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Dinitrophenols / pharmacology
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Endoplasmic Reticulum / drug effects
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Endoplasmic Reticulum / metabolism
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Endoplasmic Reticulum / ultrastructure*
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Golgi Apparatus / metabolism
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Golgi Apparatus / ultrastructure
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In Vitro Techniques
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Islets of Langerhans / metabolism
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Islets of Langerhans / ultrastructure*
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Membrane Proteins / analysis*
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Membrane Proteins / metabolism
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Models, Structural
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Proteins / analysis
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Proteins / metabolism
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Rats
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Rats, Inbred Strains
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Rats, Wistar
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Vesicular Transport Proteins
Substances
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Clathrin
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Dinitrophenols
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Membrane Proteins
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Proteins
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Sec23a protein, rat
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Vesicular Transport Proteins
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antimycin
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Antimycin A