Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

Blood. 1994 Dec 15;84(12):4008-27.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigen-Presenting Cells / metabolism*
  • Cell Differentiation / drug effects
  • Cell Line
  • Cloning, Molecular
  • Cytokines / biosynthesis
  • Cytotoxicity, Immunologic / drug effects
  • HIV Infections / physiopathology
  • Humans
  • Immunologic Factors / therapeutic use
  • Infections / physiopathology
  • Infections / therapy
  • Interleukin-12 / chemistry
  • Interleukin-12 / pharmacology
  • Interleukin-12 / physiology*
  • Interleukin-12 / therapeutic use
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology
  • Mice
  • Mice, Inbred Strains
  • Molecular Sequence Data
  • Neoplasms / immunology
  • Neoplasms / therapy
  • Protein Conformation
  • Receptors, Interleukin / genetics
  • Receptors, Interleukin / metabolism
  • Receptors, Interleukin-12
  • T-Lymphocytes, Cytotoxic* / drug effects
  • T-Lymphocytes, Cytotoxic* / immunology
  • Th1 Cells* / drug effects
  • Th1 Cells* / immunology

Substances

  • Cytokines
  • Immunologic Factors
  • Receptors, Interleukin
  • Receptors, Interleukin-12
  • Interleukin-12