Three representative cases of the clinical heterogeneity of Castleman's disease are presented: one localized form with hialine vascular histology (HV) and 2 multicentric forms corresponding to the plasmocellular variety (PC). The asymptomatic patient with HV was treated with surgical resection of one tumor. The 2 patients with the symptomatic PC variant were characterized by the different clinical presentation receiving polychemotherapy and steroids, respectively with good response. The literature is reviewed and the pathogenetic, clinical and therapeutic aspects of the disease, which remains difficult to define as a sole entity, are discussed.