Abstract
Part 1 of this update on new restorative therapeutic strategies against Parkinsons's disease focuses on transplantation of dopamine-secreting tissue. Special emphasis is put on clinical trials with fetal mesencephalic cells. Problems and potential alternative approaches are discussed. Part 2 emphasizes progress in the related field of neurotrophic factors for dopaminergic midbrain neurons.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adrenal Medulla / metabolism
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Adrenal Medulla / transplantation*
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Animals
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Brain Tissue Transplantation
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Dopamine / metabolism
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Fetal Tissue Transplantation
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Humans
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Mesencephalon / metabolism
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Mesencephalon / transplantation*
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Nerve Growth Factors / physiology*
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Parkinson Disease / physiopathology*
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Parkinson Disease / surgery*
Substances
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Nerve Growth Factors
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Dopamine