Abstract
Lymphoid neonatal cells from syngeneic donors are able to modulate the reactivity of recipient rats to MHC-incompatible vascular cardiac grafts. The suppressor splenocytes, obtained from one-day-old rats, may enhance the immunosuppressive effect of chronically administered low doses of cyclosporine (CsA).
MeSH terms
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Animals
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Animals, Newborn
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Cyclosporine / pharmacology*
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Graft Survival / drug effects
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Graft Survival / immunology*
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Heart Transplantation / immunology*
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Immunosuppression Therapy
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Lymphocytes / immunology*
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Major Histocompatibility Complex / drug effects*
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Major Histocompatibility Complex / immunology
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Male
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Rats
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Rats, Sprague-Dawley
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Spleen / cytology
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Spleen / immunology
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T-Lymphocytes, Regulatory / immunology
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Thymus Gland / cytology
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Thymus Gland / immunology
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Transplantation, Homologous / immunology