Abstract
An IgG1 monoclonal antibody generated from a mouse infected with Cryptococcus neoformans modified the course of intravenous cryptococcal infection in A/J mice by prolonging survival and reducing lung fungal burden, brain mass, and serum polysaccharide levels. The results demonstrate that C. neoformans infection can elicit useful antibodies.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Fungal / immunology*
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Antibodies, Monoclonal / immunology*
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Brain / microbiology
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Brain / pathology
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Cell Line
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Cryptococcosis / immunology*
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Cryptococcosis / microbiology
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Cryptococcosis / prevention & control
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Cryptococcus neoformans / immunology*
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Immunization, Passive
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Immunoglobulin G / immunology
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Lung / microbiology
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Lung / pathology
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Macrophages / immunology
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Mice
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Mice, Inbred A
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Mice, Inbred BALB C
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Opsonin Proteins
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Organ Size
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Polysaccharides / blood
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Polysaccharides / immunology
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Survival Analysis
Substances
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Antibodies, Fungal
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Antibodies, Monoclonal
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Immunoglobulin G
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Opsonin Proteins
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Polysaccharides
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cryptococcal polysaccharide