Abstract
The 3,5-diaminoisothiazole derivatives 23-42 were synthesized in excellent yields by oxidative cyclization of 3-amino-3-(dialkylamino)propenethioamide derivatives. These intermediates and the isothiazole derivatives were tested in vitro for their antimicrobial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology
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Bacteria / drug effects
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Fungi / drug effects
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Spectrophotometry, Infrared
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Thiazoles