The gene for the familial form of incontinentia pigmenti (IP2) maps to the distal part of Xq28

Hum Mol Genet. 1994 Feb;3(2):273-8. doi: 10.1093/hmg/3.2.273.

Abstract

Linkage data for familial incontinentia pigmenti (IP2) and 17 X chromosomal markers are reported. The linkage previously found between IP2 and the F8C locus is confirmed (Z max = 11.85 at theta = 0.028). Linkage is established with distal markers DXS1108 (Z max = 10.06 at theta = 0.00) and DXYS154 (Z = 9.07 at theta = 0.019). Multipoint analysis supports the distal localization of the IP2 gene with respect to the F8C locus.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping
  • Eye Abnormalities / genetics
  • Female
  • Genes*
  • Genetic Markers
  • Humans
  • Incontinentia Pigmenti / genetics*
  • Lod Score
  • Male
  • Mice
  • Pedigree
  • Species Specificity
  • X Chromosome*

Substances

  • Genetic Markers