Coriolus versicolor polysaccharides (CVP), extracted from Coriolus versicolor (L) Fr, were composed of 67.53% beta-D-glucose, 12.49% D-mannose, 11.49% L-abequose, 8.21% D-galactose, and trace L-acofriose. On Oregon K stock of Drosophila melanogaster, 0.5%-5% of CVP increased the number of taking food. CVP 2%, 3%, and 5% increased the frequency of mating and 0.5%-3% increased the number of flies in first filial generation (F1). CVP (2% and 3% in mated test; 1% and 2% in unmated test) prolonged the mean lifespan, the maximal lifespan, and median lethal time (LT50) of female flies, but not male flies.