Abstract
2,2-Dimethyl-6-(4-chlorophenyl)-7-phenyl, 2,3-dihydro-1H-pyrrolizine-5-yl)-acetic acid (ML 3000) is a dual inhibitor of the enzymes cyclo-oxygenase and 5-lipoxygenase in bovine and human thrombocytes and granulocytes. In animal experiments the compound has antiphlogistic, analgesic, antipyretic, antiasthmatic and antiaggregative activity at a dosage that causes no gastrointestinal damage.
MeSH terms
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Acetates / pharmacology*
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Animals
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Arachidonic Acid / antagonists & inhibitors
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Arachidonic Acid / pharmacology
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Arthritis, Experimental / drug therapy
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Benzoquinones
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Blood Coagulation / drug effects
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Bronchoconstriction / drug effects
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Carrageenan
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Cyclooxygenase Inhibitors / pharmacology*
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Edema / chemically induced
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Edema / prevention & control
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Female
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Guinea Pigs
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In Vitro Techniques
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Lipoxygenase Inhibitors / pharmacology*
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Male
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Mice
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Mice, Inbred ICR
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Pain Measurement / drug effects
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Platelet Aggregation / drug effects
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Platelet Aggregation Inhibitors / pharmacology
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Pyrroles / pharmacology*
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Rabbits
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Rats
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Rats, Sprague-Dawley
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Yeast, Dried
Substances
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Acetates
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Benzoquinones
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Cyclooxygenase Inhibitors
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Lipoxygenase Inhibitors
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Platelet Aggregation Inhibitors
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Pyrroles
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Arachidonic Acid
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phenylbenzoquinone
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Carrageenan
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licofelone