Abstract
Recent advances in the understanding of the molecular virulence mechanisms of Shigella have helped to develop a new generation of candidate Shigella vaccines. Approaches that are currently under active study include construction of hybrid Shigella-E. coli strains, performance of attenuating mutations in vitro on natural Shigella strains and acellular, lipopolysaccharide-based vaccines.
MeSH terms
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Animals
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Bacterial Vaccines*
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Biopharmaceutics
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Dysentery, Bacillary / immunology
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Dysentery, Bacillary / prevention & control*
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Humans
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Lipopolysaccharides / immunology
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Serotyping
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Shigella / classification
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Shigella / genetics
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Shigella / immunology*
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Shigella / pathogenicity
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Vaccines, Attenuated
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Vaccines, Inactivated
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Virulence / genetics
Substances
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Bacterial Vaccines
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Lipopolysaccharides
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Vaccines, Attenuated
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Vaccines, Inactivated