Retro-binding tripeptide thrombin active-site inhibitors: discovery, synthesis, and molecular modeling

J Med Chem. 1994 Jul 8;37(14):2122-4. doi: 10.1021/jm00040a001.

Authors

E J Iwanowicz¹, W F Lau, J Lin, D G Roberts, S M Seiler

Affiliation

¹ Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.

PMID: 8035417
DOI: 10.1021/jm00040a001

No abstract available

MeSH terms

Amino Acid Sequence
Binding Sites
Models, Molecular*
Molecular Sequence Data
Oligopeptides / metabolism
Serine Proteinase Inhibitors / chemical synthesis*
Structure-Activity Relationship
Thrombin / antagonists & inhibitors*
Thrombin / metabolism

Substances

Oligopeptides
Serine Proteinase Inhibitors
Thrombin