Abstract
OspC from Borrelia burgdorferi reisolated from mice persistently infected with cloned spirochetes was examined. In all cases, the sequence of the ospC gene was identical to that of the original inoculant. We conclude that variation of ospC is not necessary for evasion of the host immune system.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Bacterial Outer Membrane Proteins / analysis
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Bacterial Outer Membrane Proteins / genetics*
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Base Sequence
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Borrelia burgdorferi Group / genetics*
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Borrelia burgdorferi Group / immunology
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Chronic Disease
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Female
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Lyme Disease / immunology
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Lyme Disease / microbiology*
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Male
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Mice
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Mice, Inbred C3H
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Molecular Sequence Data
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Polymerase Chain Reaction
Substances
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Bacterial Outer Membrane Proteins