Abstract
Insulin-receptor substrate 1 (IRS-1) is a principal substrate of the receptor tyrosine kinase for insulin and insulin-like growth factor 1, and a substrate for a tyrosine kinase activated by interleukin 4. IRS-1 undergoes multisite tyrosine phosphorylation and mediates downstream signals by 'docking' various proteins that contain Src homology 2 domains. IRS-1 appears to be a unique molecule; however, 4PS, a protein found mainly in hemopoietic cells, may represent another member of this family.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing*
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Adaptor Proteins, Vesicular Transport*
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Animals
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Growth Substances / metabolism
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Humans
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Insulin / metabolism
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Insulin Receptor Substrate Proteins
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Phosphatidylinositol 3-Kinases
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Phosphoproteins / chemistry
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Phosphoproteins / metabolism*
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Phosphotransferases (Alcohol Group Acceptor) / metabolism
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Proteins / metabolism
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Shc Signaling Adaptor Proteins
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Signal Transduction*
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Src Homology 2 Domain-Containing, Transforming Protein 1
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Structure-Activity Relationship
Substances
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Adaptor Proteins, Signal Transducing
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Adaptor Proteins, Vesicular Transport
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Growth Substances
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IRS1 protein, human
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Insulin
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Insulin Receptor Substrate Proteins
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Phosphoproteins
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Proteins
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SHC1 protein, human
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Shc Signaling Adaptor Proteins
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Src Homology 2 Domain-Containing, Transforming Protein 1
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Phosphatidylinositol 3-Kinases
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Phosphotransferases (Alcohol Group Acceptor)