Abstract
We present an 84-year-old Japanese male showing typical features of bullous pemphigoid (BP). However, immunofluorescence of normal human skin sections revealed concurrent anti-basement-membrane-zone and anti-keratinocyte-cell-surface autoantibodies in the serum. With immunoblotting, the patient's serum reacted with desmoplakins I and II, as well as with both the 230-kD and the 180-kD BP antigens. The studies for this case may provide us with an insight to understand the occurrence of antidesmoplakin antibodies in paraneoplastic pemphigus.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Autoantibodies / analysis*
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Autoantigens / analysis
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Basement Membrane / immunology
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Carrier Proteins*
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Collagen Type XVII
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Collagen*
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Cytoskeletal Proteins / immunology*
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Desmoplakins
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Desmosomes / immunology
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Dystonin
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Fluorescent Antibody Technique
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Humans
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Keratinocytes / immunology
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Male
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Nerve Tissue Proteins*
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Non-Fibrillar Collagens*
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Pemphigoid, Bullous / immunology*
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Skin / immunology
Substances
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Autoantibodies
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Autoantigens
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Carrier Proteins
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Cytoskeletal Proteins
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DST protein, human
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Desmoplakins
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Dystonin
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Nerve Tissue Proteins
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Non-Fibrillar Collagens
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Collagen