Cortical and subcortical JC virus infection: two unusual cases of AIDS associated progressive multifocal leukoencephalopathy

B J Sweeney; H Manji; R F Miller; M J Harrison; F Gray; F Scaravilli

doi:10.1136/jnnp.57.8.994

Cortical and subcortical JC virus infection: two unusual cases of AIDS associated progressive multifocal leukoencephalopathy

J Neurol Neurosurg Psychiatry. 1994 Aug;57(8):994-7. doi: 10.1136/jnnp.57.8.994.

Authors

B J Sweeney¹, H Manji, R F Miller, M J Harrison, F Gray, F Scaravilli

Affiliation

¹ Department of Neurology, University College London Medical School, Middlesex Hospital, UK.

Abstract

Two patients with AIDS and progressive neurological syndromes had necropsies that identified JC virus infection of the cerebral or cerebellar cortex. The unusual presentation of progressive multifocal leukoencephalopathy with grey matter involvement and normal cerebral imaging is discussed.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

AIDS-Related Opportunistic Infections / pathology*
AIDS-Related Opportunistic Infections / physiopathology
AIDS-Related Opportunistic Infections / therapy
Adult
Biopsy
Brain Diseases / pathology*
Brain Diseases / physiopathology
Brain Diseases / therapy
Cerebellar Cortex*
Cerebral Cortex*
Fatal Outcome
HIV-1*
Humans
JC Virus*
Leukoencephalopathy, Progressive Multifocal / pathology*
Leukoencephalopathy, Progressive Multifocal / physiopathology
Leukoencephalopathy, Progressive Multifocal / therapy
Male
Papillomavirus Infections / pathology*
Papillomavirus Infections / physiopathology
Papillomavirus Infections / therapy
Tumor Virus Infections / pathology*
Tumor Virus Infections / physiopathology
Tumor Virus Infections / therapy