The last decade witnessed major advances in research in psychosocial pediatric oncology. The knowledge base has been broadened, and our ability to conduct scientifically rigorous research has advanced. Many of the research findings have affected clinical practice in significant ways. This article reviews major advances in pediatric psychosocial oncology during that period. Five topics are considered: advances in knowledge; promoters of progress; barriers to progress; current needs; and future directions. Accomplishments and new trends also are examined.