Abstract
The in vitro activity against herpes simplex virus type 1 of 3-methyl-but-2-enyl caffeate isolated from poplar buds or prepared by synthesis was investigated. Under conditions of one or multiple multiplication cycles, this compound, which is a minor constituent of propolis, was found to reduce the viral titer by 3 log10, and viral DNA synthesis by 32-fold.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Caffeic Acids / isolation & purification*
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Caffeic Acids / pharmacology
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DNA Probes
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DNA, Viral / biosynthesis
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Herpesvirus 1, Human / drug effects*
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Herpesvirus 1, Human / metabolism
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Humans
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Nucleic Acid Hybridization
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Plants, Medicinal / chemistry*
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Propolis / pharmacology*
Substances
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Antiviral Agents
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Caffeic Acids
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DNA Probes
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DNA, Viral
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1,1-dimethylallyl caffeic acid ester
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Propolis