Physical mapping of Xq24-25 around loci closely linked to the X-linked lymphoproliferative syndrome locus: an overlapping YAC map and linkage between DXS12, DXS42, and DXS37

Eur J Hum Genet. 1993;1(1):64-71. doi: 10.1159/000472388.

Abstract

We have localized several markers in the Xq24-25 region containing DXS12, DXS42 and DXS37 which are closely linked to the X-linked lymphoproliferative syndrome (XLP) locus. A 850-kb restriction map has been established by mapping overlapping YACs and showed that DXS12 and DXS42 are physically linked within about 50 kb. DXS37 is separated from these two loci at a maximum distance of 3,700 kb. Several new probes have been generated which will contribute to further physical mapping of this region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Walking*
  • Chromosomes, Artificial, Yeast*
  • DNA Probes
  • Electrophoresis, Gel, Pulsed-Field
  • Genes, Recessive
  • Genetic Linkage
  • Genetic Markers
  • Humans
  • Lymphoproliferative Disorders / genetics*
  • Restriction Mapping
  • X Chromosome*

Substances

  • DNA Probes
  • Genetic Markers