Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements

M B Knable; T M Hyde; M F Egan; M Tosayali; R J Wyatt; J E Kleinman

doi:10.1016/0006-8993(94)90081-7

Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements

Brain Res. 1994 May 23;646(2):217-22. doi: 10.1016/0006-8993(94)90081-7.

Authors

M B Knable¹, T M Hyde, M F Egan, M Tosayali, R J Wyatt, J E Kleinman

Affiliation

¹ Clinical Brain Disorders Branch, National Institute of Mental Health, St. Elizabeths Hospital, Washington, DC 20032.

PMID: 8069667
DOI: 10.1016/0006-8993(94)90081-7

Abstract

Rats treated with haloperidol that developed vacuous chewing movements (VCM), a possible animal model of tardive dyskinesia, were studied with quantitative autoradiography for dopamine type-1 (D1) and type-2 (D2) receptors as well as dopamine re-uptake sites. Haloperidol increased striatal D2 receptors, but did not affect D1 receptors or the dopamine re-uptake site. D2 receptor increases occurred in rats with and without VCMs. In so far as VCM is a model for tardive dyskinesia, haloperidol induced increases in striatal D2 receptors do not appear to be etiologic for these abnormal movements.

MeSH terms

Animals
Autoradiography / methods
Benzazepines / metabolism
Biological Transport
Corpus Striatum / metabolism*
Dopamine / metabolism*
Dopamine D2 Receptor Antagonists
Dyskinesia, Drug-Induced / metabolism*
Ligands
Male
Mastication
Piperazines / metabolism
Raclopride
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1 / metabolism*
Receptors, Dopamine D2 / metabolism*
Salicylamides / metabolism
Tritium

Substances

Benzazepines
Dopamine D2 Receptor Antagonists
Ligands
Piperazines
Receptors, Dopamine D1
Receptors, Dopamine D2
Salicylamides
Tritium
Raclopride
1-(2 (diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine
Dopamine