Abstract
It is concluded from structure predictions of the primary amino acid sequence by computer analyses that two segments of non-muscle filamin could facilitate lipid membrane attachment or anchoring. Residues 49-71 of the amino-terminal may attach to phospholipid membranes, and residues 131-155 may anchor in the hydrophobic region of lipid membranes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Contractile Proteins / chemistry*
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Filamins
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Humans
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In Vitro Techniques
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Membrane Lipids / chemistry*
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Microfilament Proteins / chemistry*
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Protein Structure, Secondary
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Sequence Analysis
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Solubility
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Structure-Activity Relationship
Substances
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Contractile Proteins
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Filamins
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Membrane Lipids
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Microfilament Proteins