The introduction of methicillin-resistant Staphylococcus aureus (MRSA) in an Amsterdam nursing home (312 beds) by a patient discharged from a local hospital, the spread of this strain to other residents and staff of the nursing home and the actions taken to prevent this spread are described. During the period when this MRSA strain was circulating residents and staff members were checked periodically for presence of MRSA. In spite of all preventive measures as implemented in Dutch hospitals (including isolation of infected residents) additional residents (in a total of 8) and staff members acquired the MRSA strain. Relaxation of the precautions (no more isolation) and continued instruction of the members of the staff was attended by a decrease of further contamination. Four of 8 residents died while being colonised or infected. The course of this epidemic illustrates that limited precautions and proper training of staff in hygiene can restrict spread of MRSA in nursing homes.