We present a series of 63 patients suffering from urothelial carcinoma (53 of the bladder and 10 of the superior urinary tract) in different stages of development. We compare the serum alpha-2 globulin figures with the different parameters making up the TNM classification of the U.I.C.C (period 1974-1979), observing that there is a hyperalpha-2 globulinemia in 40% of the tumours in the superior urinary tract and that, on the other hand, the data obtained for the bladder carcinomas are not conclusive.