Abstract
Specific radioligand binding protocols were utilized to compare the affinity of morphine and the high-potency opioid etonitazene at mu 1, mu 2, delta, kappa 1 and sigma receptors. Both etonitazene and morphine displayed a mu 1-selective binding profile; however, etonitazene had a 2500-fold higher affinity at this receptor type. The latter result is consistent with the relative potencies or morphine and etonitazene in various behavioral tests.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Benzimidazoles / metabolism*
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Benzimidazoles / pharmacology
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Guinea Pigs
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Kinetics
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Molecular Sequence Data
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Morphine / metabolism
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Morphine / pharmacology
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Radioligand Assay
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Rats
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Receptors, Opioid, delta / metabolism
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Receptors, Opioid, kappa / metabolism
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Receptors, Opioid, mu / metabolism*
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Receptors, sigma / metabolism
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Sensitivity and Specificity
Substances
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Benzimidazoles
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Receptors, Opioid, delta
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Receptors, Opioid, kappa
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Receptors, Opioid, mu
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Receptors, sigma
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Morphine