Pregnancy after liver transplantation

Int J Gynaecol Obstet. 1993 Jun;41(3):273-6. doi: 10.1016/0020-7292(93)90556-c.

Abstract

Two patients who became pregnant after liver transplantation for end-stage liver disease were carefully monitored using pulsed Doppler waveform measurements. One patient with Wilson's disease, on triple immunosuppressive therapy including prednisone, azathioprine and low-dose cyclosporin A, delivered a healthy girl weighing 2650 g after 38 weeks' gestation. The other patient, with HBV-related postnecrotic cirrhosis, became pregnant less than 3 months postoperatively, under triple therapy, after being amenorrheic for 6 years. Episodes of elevation in liver enzymes were noted, and severe osteoporosis with low back pain developed. A healthy boy weighing 2975 g was born at 35 weeks' gestation. Our cases add to previous reports of successful pregnancies under cyclosporin A immunosuppression.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Azathioprine / blood
  • Azathioprine / pharmacology
  • Azathioprine / therapeutic use
  • Blood Flow Velocity
  • Cyclosporine / blood
  • Cyclosporine / pharmacology
  • Cyclosporine / therapeutic use
  • Female
  • Follow-Up Studies
  • Humans
  • Liver Transplantation*
  • Postoperative Care
  • Prednisone / blood
  • Prednisone / pharmacology
  • Prednisone / therapeutic use
  • Pregnancy / drug effects
  • Pregnancy / physiology*
  • Ultrasonography, Prenatal
  • Umbilical Arteries / diagnostic imaging
  • Umbilical Arteries / drug effects
  • Uterus / blood supply
  • Uterus / diagnostic imaging
  • Uterus / drug effects

Substances

  • Cyclosporine
  • Azathioprine
  • Prednisone