Abstract
The possible involvement of lipopolysaccharide (LPS) and interleukin-1 beta (IL-1 beta) and their eventual interplay in CRH and ACTH release from cultured hypothalamic and pituitary cells respectively, have been studied. IL-1 beta was able to activate the hypothalamo-pituitary-adrenal axis at both hypothalamic and pituitary sites; LPS showed no direct action at hypothalamic level but it was able to inhibit basal and IL-1 beta-induced ACTH release: this could be responsible for a blunting of the adrenal cortex response that normally occurs in septic shock syndrome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenocorticotropic Hormone / antagonists & inhibitors
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Adrenocorticotropic Hormone / metabolism
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Analysis of Variance
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Animals
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Cells, Cultured
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Corticotropin-Releasing Hormone / metabolism
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Hypothalamo-Hypophyseal System / drug effects
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Hypothalamo-Hypophyseal System / metabolism*
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Interleukin-1 / pharmacology
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Interleukin-1 / physiology*
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Lipopolysaccharides / metabolism*
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Male
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Pituitary-Adrenal System / drug effects
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Pituitary-Adrenal System / metabolism*
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Rats
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Rats, Wistar
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Shock, Septic / physiopathology*
Substances
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Interleukin-1
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Lipopolysaccharides
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Adrenocorticotropic Hormone
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Corticotropin-Releasing Hormone