Abstract
A series of 2-substituted 1,4-dihydropyridines with a xanthone backbone was prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties.
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Calcium Channel Blockers / chemical synthesis*
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Calcium Channel Blockers / chemistry
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Calcium Channel Blockers / pharmacology
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Chemical Phenomena
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Chemistry, Physical
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Dihydropyridines / chemical synthesis*
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Dihydropyridines / chemistry
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Dihydropyridines / pharmacology
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Female
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Guinea Pigs
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Heart Rate / drug effects
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Mass Spectrometry
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Muscle Contraction / drug effects
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Muscle, Smooth, Vascular / drug effects
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Myocardial Contraction / drug effects
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Structure-Activity Relationship
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Xanthines / chemical synthesis*
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Xanthines / chemistry
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Xanthines / pharmacology
Substances
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Calcium Channel Blockers
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Dihydropyridines
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Xanthines