Abstract
We have shown that the insulin-like growth factor type I and II receptors are expressed equally from the maternal and paternal alleles in human tissues. The imprinting status of the type I insulin-like growth factor receptor has not been reported while the type II receptor has previously been shown to be maternally expressed in the mouse. That the imprinting of the insulin-like growth factor type II receptor is not conserved between mouse and humans suggests that the physiological role of the IGF2 receptor may differ between these two species.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Base Sequence
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DNA Primers
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Female
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Fetus
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Humans
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Kidney / embryology
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Kidney / metabolism
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Kidney Neoplasms / genetics
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Kidney Neoplasms / metabolism
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Male
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Molecular Sequence Data
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Polymerase Chain Reaction / methods
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Polymorphism, Genetic
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Pregnancy
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Receptor, IGF Type 1 / biosynthesis
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Receptor, IGF Type 1 / genetics*
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Receptor, IGF Type 2 / biosynthesis
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Receptor, IGF Type 2 / genetics*
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Repetitive Sequences, Nucleic Acid
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Transcription, Genetic
Substances
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DNA Primers
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Receptor, IGF Type 2
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Receptor, IGF Type 1