Abstract
Mouse transcription factor A1 (A1) is a mouse homologue of human E47, a ubiquitously expressed DNA-binding protein which contains a basic region, helix-loop-helix (HLH) and leucine zipper (LZ) motifs [Walker et al., Nucleic Acids Res. 18 (1990) 1159-1166]. Analyses of the nucleotide (nt) sequences of A1 cDNAs isolated from various mouse strains revealed amino acid (aa) polymorphism in the highly conserved region within the LZ motif. Interestingly, the location and pattern of aa deletions are identical to those previously described for the aa polymorphism within the human counterpart, E47 (E12) [Kamps et al., Cell 60 (1990) 547-555].
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Basic Helix-Loop-Helix Transcription Factors
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DNA, Complementary / genetics*
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics*
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Leucine Zippers / genetics*
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Mice
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Molecular Sequence Data
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Polymorphism, Genetic / genetics
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Transcription Factors / chemistry
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Transcription Factors / genetics*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA, Complementary
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DNA-Binding Proteins
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Tcf3 protein, mouse
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Transcription Factors
Associated data
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GENBANK/D16631
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GENBANK/D16632
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GENBANK/D16633
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GENBANK/D16634
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GENBANK/D16635
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GENBANK/D16636
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GENBANK/D16637
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GENBANK/D16638
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GENBANK/D29919