Cancer frequently metastasizes to the brain, and such lesions, whether multiple or solitary, have a poor prognosis, despite all efforts to treat them. There have been recent sporadic reports of brain metastases from breast cancer responding for some years to antiestrogens (particularly tamoxifen) or bromocriptine. We report three cases of brain metastasis from cancer--two multiple and one a solitary lesion. The long survival of the patients--two for 5 years and one for 6 years, with more than an acceptable quality of life - should prompt therapeutic trials to test tamoxifen and designed to assess its effects on a sizable number of patients.