Kawasaki disease (KD) is an acute illness encountered in infancy and childhood. Cardiovascular complications of this syndrome are recognized as being part of the adult coronary artery disease population. Reported herein is the surgical treatment of multiple coronary artery aneurysms, severe stenotic lesions and thrombotic involvement of the coronary arterial tree that could be ascribed to childhood KD in two adult patients with no risk factors for atherosclerotic heart disease. Surgical management of such patients reveals safe and provides satisfactory quality of life.