Determination of S 12024 enantiomers in human plasma by liquid chromatography after chiral pre-column derivatization

J Pharm Biomed Anal. 1993 Nov-Dec;11(11-12):1161-6. doi: 10.1016/0731-7085(93)80099-m.

Abstract

S 12024-2 is a new drug in phase II development that possesses cognitive enhancing properties. As its molecular structure has a chiral centre, a stereoselective method for the analysis of both enantiomers in human plasma has been developed. The method involves pre-column derivatization of the amine moiety with a homochiral reagent (+)-1-(9-fluorenyl)ethyl chloroformate (FLEC), and chromatographic separation of the two diastereoisomers on an achiral reversed-phase cyanopropyl column, with fluorimetric detection (lambda ex = 260 nm; lambda em = 310 nm). A liquid-liquid extraction procedure with diethyl ether-dichloromethane (70:30, v/v) was used for sample preparation. This technique provides a linear response for both enantiomers over a concentration range of 10-500 ng ml-1 and the quantitation limit was set at 5 ng ml-1 in human plasma. Within-day and between-day precision and accuracy are within 9% limits for all concentrations assessed. This procedure was therefore used for determining both enantiomers in human plasma following oral administration of racemic S 12024-2 to elderly healthy subjects.

MeSH terms

  • Administration, Oral
  • Aged
  • Amines / chemistry
  • Chromatography, Liquid*
  • Humans
  • Morpholines / administration & dosage
  • Morpholines / blood*
  • Quinolines / administration & dosage
  • Quinolines / blood*
  • Regression Analysis
  • Reproducibility of Results
  • Spectrometry, Fluorescence
  • Stereoisomerism

Substances

  • Amines
  • Morpholines
  • Quinolines
  • S 12024