Abstract
The EEGraphic, behavioural and autonomic effects related to the separated and simultaneous central administration of CRF and CRF antagonist (alpha-helical CRF 9-41) were evaluated in the rabbit. CRF produced a decrease of cortical EEG power spectrum, a biphasic effect on the heart rate, a hyperthermia and tachypnoea. 9-41 CRF significantly increased the EEG power spectrum, but it did not affect the autonomic parameters. The simultaneous administration of these peptides resulted in a significative and rapid inhibition of all the CRF effects. The intrinsic properties of 9-41 CRF on EEG and the interaction with CRF were discussed.
MeSH terms
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Animals
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Autonomic Nervous System / drug effects*
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Behavior, Animal / drug effects*
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Body Temperature / drug effects
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Corticotropin-Releasing Hormone / administration & dosage
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Corticotropin-Releasing Hormone / antagonists & inhibitors*
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Corticotropin-Releasing Hormone / chemistry
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Corticotropin-Releasing Hormone / pharmacology*
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Electroencephalography / drug effects*
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Hemodynamics / drug effects
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Injections, Intraventricular
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Peptide Fragments / administration & dosage
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Peptide Fragments / chemistry
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Peptide Fragments / pharmacology*
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Protein Structure, Secondary
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Rabbits
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Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*
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Respiration / drug effects
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Structure-Activity Relationship
Substances
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Peptide Fragments
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Receptors, Corticotropin-Releasing Hormone
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Corticotropin-Releasing Hormone
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corticotropin releasing hormone (9-41)