Abstract
Some new anionic complexes of organo-tin(IV) and lead (IV) isolated in combination of tetraorgano-ammonium phosphonium and stibonium cation(s). L[R4-nMXnY] and L2[R2MX2Y2], where R = C2H5, C4H9 or C6H5; M = Sn or Pb; X = Y = Cl = Br, I, N3, NCS; n = 1, 2 and L = R4M1 (M1 = N, P, Sb), whose structures were confirmed by correct elemental analyses, molar conductance values, van't Hoff factor and IR spectral studies, were synthesized and evaluated for anti-convulsant activity in vivo and antiviral and antibacterial activity in vitro. A few of them exhibited promising activity. In addition, the toxicity (ALD50) and effects on the central nervous system of these complexes have been studied in mice.
MeSH terms
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Animals
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Anti-Bacterial Agents
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / pharmacology
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Anticonvulsants / chemical synthesis
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Anticonvulsants / pharmacology
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology
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Bacteria / drug effects
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Central Nervous System / drug effects
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Female
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Fungi / drug effects
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Lead / pharmacology*
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Lead / toxicity
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Lethal Dose 50
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Male
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Mice
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Microbial Sensitivity Tests
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / pharmacology
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Organometallic Compounds / toxicity
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Organotin Compounds / chemical synthesis*
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Organotin Compounds / pharmacology*
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Organotin Compounds / toxicity
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Spectrophotometry, Infrared
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Anticonvulsants
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Antifungal Agents
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Organometallic Compounds
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Organotin Compounds
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Lead