Neonatal allo-immune thrombocytopenia due to fetomaternal HPA-1 incompatibility of a homozygous HPA-1a mother and a homozygous HPA-1b father. A case report

Eur J Pediatr. 1994 Feb;153(2):95-7. doi: 10.1007/BF01959215.

Abstract

We report a case of neonatal allo-immune thrombocytopenia due to fetomaternal human platelet antigen (HPA)-1 incompatibility. Anit-HPA-1b antibodies were detectable in maternal serum. Repeated treatment of the infant with high-dose IgG effectively raised platelet counts transiently, but the patient remained thrombocytopenic for more than 6 weeks. Serological and DNA analysis revealed that the mother was homozygous HPA-1a and the father homozygous HPA-1b.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Human Platelet / genetics
  • Antigens, Human Platelet / immunology*
  • Female
  • Homozygote
  • Humans
  • Infant, Newborn
  • Isoantibodies / blood
  • Male
  • Maternal-Fetal Exchange / immunology*
  • Platelet Count
  • Pregnancy
  • Thrombocytopenia / blood
  • Thrombocytopenia / etiology
  • Thrombocytopenia / immunology*

Substances

  • Antigens, Human Platelet
  • Isoantibodies