Abstract
The mouse IRS-1 gene has been cloned and its structure determined. Mouse IRS-1 differs from rat by the absence of the potential C-terminal nucleotide binding site. Otherwise, the predicted IRS-1 protein is highly conserved between mouse, rat and humans, especially in the possible phosphorylation sites. The highly conserved nature of IRS-1 suggests the importance of these domains in the function of IRS-1 or its association with other proteins.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Binding Sites
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Cloning, Molecular
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DNA, Complementary / genetics
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Humans
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Insulin Receptor Substrate Proteins
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Mice
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Molecular Sequence Data
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Phosphoproteins / genetics*
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Phosphoproteins / metabolism
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Rats
Substances
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DNA, Complementary
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IRS1 protein, human
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Insulin Receptor Substrate Proteins
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Irs1 protein, mouse
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Irs1 protein, rat
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Phosphoproteins