Abstract
The immunogenic properties and protective activity of basic protein I and tris-soluble antigens isolated from R. prowazekii were analyzed in comparison with those of chemical typhus vaccine on the model of anti-infectious immunity in guinea pigs. The analysis revealed that purified protein I has protective activity for guinea pigs, which is less pronounced in protein I from strain E with weak pathogenicity than protein I from strains EVir and Breinl. The activity and immunogenic properties of tris-soluble antigens, especially antigen I, are comparable with those of chemical typhus vaccines in the parameters under study.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Antibodies, Bacterial / blood
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Antigens, Bacterial / immunology*
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Antigens, Bacterial / isolation & purification
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Antigens, Surface / immunology
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Antigens, Surface / isolation & purification
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Bacterial Proteins / immunology*
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Bacterial Proteins / isolation & purification
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Bacterial Vaccines / immunology
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Chick Embryo
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Guinea Pigs
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Immunization
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Immunization, Secondary
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Male
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Rickettsia prowazekii / immunology*
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Serial Passage
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Solubility
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Time Factors
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Typhus, Epidemic Louse-Borne / immunology
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Typhus, Epidemic Louse-Borne / prevention & control
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Antigens, Surface
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Bacterial Proteins
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Bacterial Vaccines