Abstract
The relationship between CCl4 or (CCl4 + phenobarbital)-induced liver cirrhosis and diethylnitrosamine (DEN) hepatocarcinogenesis in male F-344 rats was investigated. DEN given alone produced no liver lesions after 16 weeks, but 4/12 (33%) neoplastic nodules developed when nitrosamine was administered to rats with previously established cirrhosis. On the other hand, (CCl4 + phenobarbital) post-treatment had an even stronger effect, increasing the yield of neoplastic nodules to 100% (28/28). Since the exposure time of DEN was the same in all treated groups (4 months), the results indicate the decreased effectiveness of (CCl4 + phenobarbital) pretreatment on DEN hepatocarcinogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbon Tetrachloride / toxicity
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Carbon Tetrachloride Poisoning / pathology*
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Diethylnitrosamine / toxicity*
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Liver / drug effects
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Liver / pathology*
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Liver Cirrhosis, Experimental / chemically induced
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Liver Cirrhosis, Experimental / pathology*
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Liver Neoplasms, Experimental / chemically induced
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Liver Neoplasms, Experimental / pathology*
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Liver Neoplasms, Experimental / prevention & control
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Male
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Phenobarbital / toxicity*
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Precancerous Conditions / chemically induced
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Precancerous Conditions / pathology*
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Precancerous Conditions / prevention & control
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Rats
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Rats, Inbred F344
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Time Factors
Substances
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Diethylnitrosamine
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Carbon Tetrachloride
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Phenobarbital