Some comments on potency measures in mutagenicity research

B H Margolin; B S Kim; M G Smith; B A Fetterman; W W Piegorsch; E Zeiger

doi:10.1289/ehp.94102s191

Some comments on potency measures in mutagenicity research

Environ Health Perspect. 1994 Jan;102 Suppl 1(Suppl 1):91-4. doi: 10.1289/ehp.94102s191.

Authors

B H Margolin¹, B S Kim, M G Smith, B A Fetterman, W W Piegorsch, E Zeiger

Affiliation

¹ Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill 27599-7400.

Abstract

In this article, the measurement of the potency of a chemical or mixture from its dose response in a particular assay is addressed. Attention is focused on data from the Ames Salmonella assay. Three measures of potency are explored and shown to be highly correlated. The presentation then discusses specific areas of research that might benefit from a study of potency.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Dose-Response Relationship, Drug
Hazardous Substances / toxicity*
Mutagenicity Tests / statistics & numerical data
Salmonella / drug effects*

Substances

Hazardous Substances

Abstract

Publication types

MeSH terms

Substances

Grants and funding