Abstract
Cigarette smoking condensate and diethylnitrosamine can initiate human lung carcinogenesis as they are able to induce precancerous lesions of bronchioles and the transforming ability of human fetal lung (HFL) DNA. The induction of precancerous lesions in HFL and the acquirement of the transforming ability of HFL DNA by short-term exposure to carcinogens can be combined to yield an ideal model for the initiation of human lung carcinogenesis.
MeSH terms
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Animals
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Cell Transformation, Neoplastic / chemically induced
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / pathology*
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DNA, Neoplasm / genetics
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Diethylnitrosamine
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Humans
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Lung Neoplasms / chemically induced
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Lung Neoplasms / genetics
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Lung Neoplasms / pathology*
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Methylnitrosourea
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Mice
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Mice, Nude
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Neoplasm Transplantation
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Precancerous Conditions / chemically induced
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Precancerous Conditions / genetics
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Precancerous Conditions / pathology*
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Rats
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Transfection
Substances
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DNA, Neoplasm
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Diethylnitrosamine
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Methylnitrosourea