The epidemiologic picture of the injured in traffic accidents in the Nis region in the last five years (1998-1992) is presented. The analysis was performed of number, types, causes and consequences of traffic accidents with injured and killed people. Traffic accidents most commonly occurred in May and August, during weekends (Friday and Saturday) between 16 and 20 hrs and in the etiology dominated the human factor. These traffic accidents most often cause injuries of the locomotor system, craniocerebral damages and polytrauma. The first on the list of fatalities are drivers of vehicles. The transport of the injured to medical institutions most commonly is inadequate (civil vehicles). Owing to these facts it is necessary to undertake urgently adequate preventive measures in order to reduce the number of traffic accidents and more effective management of the injured.