Abstract
A bioassay guided fractionation of an extract of Chinese licorice roots led to the isolation of (E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-[4- hydroxy-3-(3-methyl-2-butenyl]phenyl-2-propen-1-one, which in vitro showed potent antileishmanial activity. In addition, the novel chalcone (E)-1-[2,4-dihydroxy-3-(3-methyl-2- butenyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-prope n-1-one was isolated from the roots. The latter compound only showed antileishmanial activity at high concentrations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / isolation & purification
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Antiprotozoal Agents / pharmacology*
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Chalcone / analogs & derivatives*
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Chalcone / chemistry
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Chalcone / isolation & purification
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Chalcone / pharmacology
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Chalcones
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China
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Glycyrrhiza / chemistry*
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Leishmania donovani / drug effects*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plants, Medicinal*
Substances
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1-(2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl)-3-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-2-propen-1-one
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Antiprotozoal Agents
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Chalcones
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1-(3-(3-methyl-2-butenyl)-2,4-(dihydroxy)phenyl)-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)-2-propen-1-one
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Chalcone